« Previous
Next »
Seminars in Pediatric Neurology
Volume 12, Issue 1
, Pages 15-24
, March 2005
The Long QT and Brugada Syndromes: Causes of Unexpected Syncope and Sudden Cardiac Death in Children and Young Adults
References
- . Cellular basis and mechanism underlying normal and abnormal myocardial repolarization and arrhythmogenesis . Ann Med . 2004;36(Suppl 1):5–14
-
.
Genetics of cardiac arrhythmias and sudden cardiac death
.
Ann NY Acad Sci
. 2004;1015:96–110
- . Congenital deaf-mutism, functional heart disease with prolongation of the QT interval, and sudden death . Am Heart J . 1957;54:59–68
-
.
Aritmie cardiache rare dell’eta pediatrica
.
Clin Pediatr
. 1963;45:656–683
- . A new familial cardiac syndrome in children . J Ir Med Assoc . 1964;54:103–106
-
Spectrum of mutations in Long-QT Syndrome genes KVLQT1, HERG, SCN5A, KCNE1, and KCNE2
.
Circulation
. 2000;102:1178–1185
- Mapping of a gene for long QT syndrome to chromosome 4q25-27 . Am J Hum Genet . 1995;57:1114–1122
- Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death . Nature . 2003;421:634–639
- Functional and clinical characterization of KCNJ2 mutations associated with LQT7 (Andersen syndrome) . J Clin Invest . 2002;110:381–388
- An intronic mutation causes long QT syndrome . J Am Coll Cardiol . 2004;44:1283–1291
- KvLQT1 and IsK (minK) proteins associate to form the IKs cardiac potassium current . Nature . 1996;384:78–80
- Co-assembly of KvLQT1 and minK (IsK) proteins to form cardiac Iks potassium channel . Nature . 1996;384:80–83
- A mechanistic link between an inherited and an acquired cardiac arrhythmia (HERG encodes the IKr potassium channel) . Cell . 1995;81:299–307
-
Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia
.
Proc Natl Acad Sci USA
. 1996;93:2208–2212
- SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome . Cell . 1995;80:805–811
- Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia . Hum Mol Genet . 1995;4:1603–1607
- Genomic organization of the human SCN5A gene encoding the cardiac sodium channel . Genomics . 1996;34:9–16
- Electrophysiological characterization of SCN5A mutations causing long QT (E1784K) and Brugada (R1512W and R1432G) syndromes . [see comments] Cardiovasc Res . 2000;46:55–65
- Molecular basis of the long-QT syndrome associated with deafness . Proc Assoc Am Physicians . 1997;109:504–511
- A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome . Nat Genet . 1997;15:186–189
- Autosomal recessive long-QT syndrome (Jervell Lange-Nielsen syndrome) is genetically heterogeneous . Hum Genet . 1997;100:573–576
- KCNE1 mutations cause Jervell and Lange-Nielsen syndrome . Nat Genet . 1997;17:267–268
- Mutation of the gene for IsK associated with both Jervell and Lange-Nielsen and Romano-Ward forms of Long-QT syndrome . Circulation . 1998;97:142–146
- ECG T-wave patterns in genetically distinct forms of the hereditary long QT syndrome . Circulation . 1995;92:2929–2934
-
The spectrum of ST-T wave patterns and repolarization parameters in congenital long QT syndrome
(ECG findings identify genotype)
.
Circulation
. 2000;102:2849–2855
-
Genotype-phenotype correlation in the long QT syndrome. Gene-specific triggers for life-threatening arrhythmias
.
Circulation
. 2001;103:89–95
- Auditory stimuli as a trigger for arrhythmic events differentiate HERG-related (LQTS2) patients from KVLQT1-related patients (LQTS1) . J Am Coll Cardiol . 1999;33:327–332
- . Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome (effects of beta-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes) . Circulation . 1998;98:2314–2322
- The spectrum of symptoms and QT Intervals in the carriers of the gene for the long-QT syndrome . N Engl J Med . 1992;327:846–852
-
Snarr B, Zhang L, Vincent GM: QTc interval variability on serial ECG’s in patients with the LQT1 form of long QT syndrome. Pacing Clin Electrophysiol 24 [Part II (356)], 627. 4-1-2001
- Diagnostic criteria for the long QT syndrome (an update) . Circulation . 1993;88:782–784
- Epinephrine-induced QT interval prolongation (a gene-specific paradoxical response in congenital long QT syndrome) . Mayo Clin Proc . 2002;77:413–421
- Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene . Science . 1991;252:704–706
- Influence of genotype on the clinical course of the long-QT syndrome . N Engl J Med . 1998;339:960–965
- Risk stratification in the long-QT syndrome . N Engl J Med . 2003;348:1866–1874
- . The long-QT syndrome—bedside to bench to bedside . N Engl J Med . 2003;348:1837–1838
- . Clinical management of patients with the long QT syndrome (drugs, devices, and gene-specific therapy) . [Review] Pacing Clin Electrophysiol . 1997;20:2058–2060
- . Management of patients with the hereditary long QT syndrome . J Cardiovasc Electrophysiol . 1998;9:668–674
- Genetic and molecular basis of cardiac arrhythmias: Impact on clinical management. Part. III . Circulation . 1999;99:674–681
- Genetic and molecular basis of cardiac arrhythmias: Impact on clinical management. Parts. I and II . Circulation . 1999;99:518–528
-
.
Beta-blockers markedly reduce risk and syncope in KVLQT1 long QT patients
.
Circulation
. 1996;94(Suppl. 1):I-204
- Permanent cardiac pacing in patients with the long QT syndrome . J Am Coll Cardiol . 1987;10:600–607
- Combined used of beta-adrenergic blocking agents and long term cardiac pacing for patients with the long QT syndrome . J Am Coll Cardiol . 1992;20:830–837
- . Cardiac pacing in the long QT syndrome (review of available data and practical recommendations) . J Cardiovasc Electrophysiol . 2000;11:593–600
- . Long QT syndrome associated with syndactyly in a female . [letter; comment] Am J Cardiol . 1996;78:380
- . Long QT syndrome associated with syndactyly identified in females . Am J Cardiol . 1995;76:744–745
- A new form of long QT syndrome associated with syndactyly . [Review] J Am Coll Cardiol . 1995;25:59–64
- A molecular basis for cardiac arrhythmia (HERG mutations cause long QT syndrome) . Cell . 1995;80:795–803
- Genetically defined therapy of inherited long-QT syndrome. Correction of abnormal repolarization by potassium . Circulation . 1996;94:1018–1022
-
Etheridge SP, Compton SJ, Pursley M, Kurkhardt J, Shepperd T, Mason JW: Chronic potassium shortens QTc in long QT patients with IKr defects. Pacing Clin Electrophysiol 24[Part II (271)], 606. 4-1-2001
- Long-term (subacute) potassium treatment in congenital HERG-related long QT syndrome (LQTS2) . J Cardiovasc Electrophysiol . 1999;10:229–233
- Differential response to Na+ channel blockade, beta-adrenergic stimulation, and rapid pacing in a cellular model mimicking the SCN5A and HERG defects present in the long QT syndrome . Circ Res . 1996;78:1009–1015
- . A molecular basis for the therapy of the long QT syndrome . Arch Mal Coeur Vaiss . 1996;89:1185–1187
- Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate (implications for gene-specific therapy) . Circulation . 1995;92:3381–3386
- . Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 and LQT3 models of the long-QT syndrome . Circulation . 1997;96:2038–2047
- Effects of sodium channel block with mexiletine to reverse action potential prolongation in in vitro models of the long term QT syndrome . J Cardiovasc Electrophysiol . 1997;8:1280–1290
- . Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report . J Am Coll Cardiol . 1992;20:1391–1396
- . Ethnomedical pathogenesis and Hmong immigrants’ sudden nocturnal deaths . Cult Med Psychiatry . 1994;18:23–59
- . Sudden unexpected nocturnal death syndrome in the Mariana Islands . Am J Forensic Med Pathol . 1990;11:205–207
-
Right bundle branch block, right precordial ST-segment elevation, and sudden death in young people
.
Circulation
. 2001;103:710–717
- Genetic and biophysical basis of sudden unexplained nocturnal death syndrome (SUNDS), a disease allelic to Brugada syndrome . Hum Mol Genet . 2002;11:337–345
- Arrhythmogenic marker for the sudden unexplained death syndrome in Thai men . Circulation . 1997;96:2595–2600
- Epidemiology of sudden unexpected death syndrome among Thai migrant workers in Singapore . Int J Epidemiol . 1993;22:88–95
- . Bangungut in Manila (sudden and unexplained death in sleep of adult Filipinos) . Int J Epidemiol . 1998;27:677–684
- Sudden and unexplained deaths in sleep (Laitai) of young men in rural northeastern Thailand . Int J Epidemiol . 1992;21:904–910
- Prevalence and prognosis of subjects with Brugada-type ECG pattern in a young and middle-aged Finnish population . Eur Heart J . 2004;25:874–878
- . Prevalence of the Brugada electrocardiographic pattern at the Medical Center of Louisiana in New Orleans . J La State Med Soc . 2003;155:242–246
- Clinical and molecular heterogeneity in the Brugada syndrome (a novel gene locus on chromosome 3) . Circulation . 2002;105:707–713
- Genotype-phenotype relationship in Brugada syndrome (electrocardiographic features differentiate SCN5A-related patients from non-SCN5A-related patients) . J Am Coll Cardiol . 2002;40:350–356
- . The Brugada syndrome (ionic basis and arrhythmia mechanisms) . J Cardiovasc Electrophysiol . 2001;12:268–272
- Loss of function associated with novel mutations of the SCN5A gene in patients with Brugada syndrome . Can J Cardiol . 2004;20:425–430
- Spatial and temporal heterogeneity of depolarization and repolarization may complicate implantable cardioverter defibrillator therapy in Brugada Syndrome . J Cardiovasc Electrophysiol . 2000;11:516–521
- Delay in right ventricular activation contributes to Brugada syndrome . Circulation . 2004;109:1272–1277
- Genetic and biophysical basis of sudden unexplained nocturnal death syndrome (SUNDS), a disease allelic to Brugada syndrome . Hum Mol Genet . 2002;11:337–345
-
Clinical and genetic heterogeneity of right bundle branch block and ST-segment elevation syndrome. A prospective evaluation of 52 families
.
Circulation
. 2000;102:2509–2515
- Prevalence and prognosis of subjects with Brugada-type ECG pattern in a young and middle-aged Finnish population . Eur Heart J . 2004;25:874–878
- . Prevalence of the Brugada electrocardiographic pattern at the Medical Center of Louisiana in New Orleans . J La State Med Soc . 2003;155:242–246
- . Right bundle-branch block and ST-segment elevation in leads V1 through V3 (a marker for sudden death in patients without demonstrable structural heart disease) . Circulation . 1998;97:457–460
-
Grillo M, Bloise R, Faggiano G, Cerrone M, Vicentini A, Barbaro C, Moncalvo C, Napolitano C, Schwartz PJ, Priori SG: Electrocardiographic characteristics in Brugada syndrome do not predict clinical outcome. Pacing Clin Electrophysiol 24[Part II (199)], 588. 4-1-2001
- Prevalence and prognosis of subjects with Brugada-type ECG pattern in a young and middle-aged Finnish population . Eur Heart J . 2004;25:874–878
- Relatively benign clinical course in asymptomatic patients with Brugada-type electrocardiogram without family history of sudden death . J Cardiovasc Electrophysiol . 2001;12:2–6
-
Two distinct congenital arrhythmias evoked by a multidysfunctional Na(+) channel
.
Circ Res
. 2000;86:E91–E97
- . Efficacy of quinidine in high-risk patients with Brugada syndrome . Circulation . 2004;110:1731–1737
PII: S1071-9091(04)00108-1
doi: 10.1016/j.spen.2004.11.008
© 2005 Elsevier Inc. All rights reserved.
« Previous
Next »
Seminars in Pediatric Neurology
Volume 12, Issue 1
, Pages 15-24
, March 2005
