Seminars in Pediatric Neurology
Volume 12, Issue 2 , Pages 97-105 , June 2005

Neonatal Seizures: To Treat Or Not To Treat?

  • Elaine C. Wirrell, MD (FRCPC)

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Elaine C. Wirrell, MD, FRCPC, Division of Pediatric Neurology, Alberta Childrens Hospital, 1820 Richmond Rd SW, Calgary, AB, Canada T2T 5C7.

References 

  1. Ronen GM , Penney S , Andrews W . The epidemiology of clinical neonatal seizures in Newfoundland (a population-based study) . J Pediatr . 1999;134:71–75
  2. Lanska MJ , Lanska DJ , Baumann RJ , et al.   A population-based study of neonatal seizures in Fayette County, Kentucky . Neurology . 1995;45:724–732
  3. Saliba RM , Annegers JF , Waller DK , et al.   Incidence of neonatal seizures in Harris County, Texas . Am J Epidemiol . 1999;150:763–769
  4. Miller V . Neonatal cerebral infarction . Semin Pediatr Neurol . 2000;7:278–288
  5. Marret S , Lardennois C , Mercier A , et al.   Fetal and neonatal cerebral infarcts . Biol Neonate . 2001;79:236–240
  6. Volpe J . Neonatal seizures . In:  Volpe J editors. Neurology of the Newborn . (ed 3). Philadelphia, PA: Saunders; 1995;p. 172–207
  7. Holden KR , Mellits ED , Freeman JM . Neonatal seizures I. Correlation of prenatal and perinatal events with outcomes . Pediatrics . 1982;70:165–176
  8. Camfield PR . Recurrent seizures in the developing brain are not harmful . Epilepsia . 1997;38:735–737
  9. Wasterlain CG . Recurrent seizures in the developing brain are harmful . Epilepsia . 1997;38:728–734
  10. Wasterlain CG , Shirasaka Y . Seizures, brain damage and brain development . Brain Dev . 1994;16:279–295
  11. Holmes GL , Ben-Ari Y . The neurobiology and consequences of epilepsy in the developing brain . Pediatr Res . 2001;49:320–325
  12. Maytal J , Shinnar S , Moshe SL , et al.   Low morbidity and mortality of status epilepticus in children . Pediatrics . 1989;83:323–331
  13. Hagberg H , Bona E , Gilland E , et al.   Hypoxia-ischaemia model in the 7-day-old rat (Possibilities and shortcomings) . Acta Paediatr Suppl . 1997;422:85–88
  14. Dobbing J , Sands J . Comparative aspects of the brain growth spurt . Early Hum Dev . 1979;3:79–83
  15. Holmes GL . Epilepsy in the developing brain (lessons for the laboratory and clinic) . Epilepsia . 1997;38:12–30
  16. Albala BJM , Moshe SL , Okada R . Kainic-acid induced seizures (a developmental study) . Brain Res . 1984;13:139–148
  17. Nitecka L , Tremblay E , Charton G , et al.   Maturation of kainic acid seizure-brain damage syndrome in the rat. 2. Histopathological sequelae . Neuroscience . 1984;13:1073–1094
  18. Stafstrom CE , Thompson JL , Holmes GL . Kainic acid seizures in the developing brain (status epilepticus and spontaneous recurrent seizures) . Dev Brain Res . 1992;65:227–236
  19. Stafstrom CE , Holmes GL , Chronopoulos A , et al.   Age-dependent cognitive and behavior deficits following kainic acid-induced seizures . Epilepsia . 1993;33:420–432
  20. Liu Z , Mikati M , Holmes GL . Mesial temporal sclerosis (pathogenesis and significance) . Pediatr Neurol . 1995;12:5–16
  21. Sankar R , Shin DH , Liu H , et al.   Patterns of status epilepticus-induced neuronal injury during development and long-term consequences . J Neurosci . 1998;18:8382–8393
  22. Friede RL . Developmental Neuropathology . (ed 2). Berlin: Springer-Verlag; 1989;
  23. Kubova H , Druga R , Lukasiuk K , et al.   Status epilepticus causes necrotic damage in the mediodorsal nucleus of the thalamus in immature rats . J Neurosci . 2001;21:3593–3599
  24. Franck JE , Schwartzkroin PA . Immature rabbit hippocampus is damaged by systemic but not intraventricular kainic acid . Dev Brain Res . 1984;13:219–227
  25. Towfighi J , Housman C , Brucklacher R , et al.   Neuropathology of seizures in the immature rabbit . Dev Brain Res . 2004;152:143–152
  26. Neill JC , Liu Z , Sarkisian M , et al.   Recurrent seizures in immature rats (effect on auditory and visual discrimination) . Dev Brain Res . 1996;95:283–292
  27. Holmes GL , Gaiarsa JL , Chevassus-Au-Louis N , et al.   Consequences of neonatal seizures in the rat (morphological and behavioral effects) . Ann Neurol . 1998;44:845–857
  28. Huang L , Cilio MR , Silveira DC , et al.   Long-term effects of neonatal seizures (a behavioral, electrophysiological and histological study) . Dev Brain Res . 1999;118:99–107
  29. Lynch M , Sayin U , Bownds J , et al.   Long-term consequences of early postnatal seizures on hippocampal learning and plasticity . Eur J Neurosci . 2000;12:2252–2264
  30. Holmes GL , Sarkisian M , Ben-Ari Y , et al.   Mossy fiber sprouting after recurrent seizures during early development in rats . J Comp Neurol . 1999;404:537–553
  31. Thompson K , Holm AM , Schousboe A , et al.   Hippocampal stimulation produces neuronal death in the immature brain . Neuroscience . 1998;82:337–348
  32. Koh S , Storey TW , Santos TC , et al.   Early-life seizures in rats increase susceptibility to seizure-induced brain injury in adulthood . Neurology . 1999;53:915–921
  33. Schmid R , Tandon P , Stafstrom CE , et al.   Effects of neonatal seizures on subsequent seizure-induced brain injury . Neurology . 1999;53:1754–1761
  34. Koh S , Jensen FE . Topirimate blocks perintal hypoxia-induced seizures in rat pups . Ann Neurol . 2001;50:366–372
  35. LaMantia AS . The usual suspects (GABA and glutamate may regulate proliferation in the neocortex) . Neuron . 1995;15:1223–1225
  36. LoTurco JJ , Owens DF , Heath MJ , et al.   GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis . Neuron . 1995;15:1287–1298
  37. Johnston MV . Developmental aspects of epileptogenesis . Epilepsia . 1996;37(suppl 1):S2–S9
  38. Jiang M , Lee CL , Smith LK , et al.   Spine loss and other persistent alterations of hippocampal pyramidal cell dendrites in a model of early-onset epilepsy . J Neurosci . 1998;18:8356–8368
  39. Montgomery EM , Bardgett ME , Lall B , et al.   Delayed neuronal loss after administration of intracerebroventricular kainic acid to preweanling rats . Dev Brain Res . 1999;112:107–116
  40. Cataltepe O , Vannucci RC , Heitjan DF , et al.   Effect of status epilepticus on hypoxic-ischemic brain damage in the immature rat . Pediatr Res . 1995;38:251–257
  41. Towfighi J , Housman C , Mauger D , et al.   Effect of seizures on cerebral hypoxic-ischemic lesions in immature rats . Brain Res Dev Brain Res . 1999;113:83–95
  42. Wirrell EC , Armstrong EA , Osman LD , et al.   Prolonged seizures exacerbate perinatal hypoxic-ischemic brain damage . Pediatr Res . 2001;50:445–454
  43. Rice JE , Vannucci RC , Brierly JB . The influence of immaturity on hypoxic-ischemic brain damage in the rat . Ann Neurol . 1981;9:131–141
  44. Yager JY , Armstrong EA , Miyashita H , et al.   Prolonged neonatal seizures exacerbate hypoxic-ischemic brain damage (correlation with cerebral energy metabolism and excitatory amino acid release) . Dev Neurosci . 2002;24:367–381
  45. Miller SP , Weiss J , Barnwell A , et al.   Seizure-associated brain injury in term infants with perinatal asphyxia . Neurology . 2002;58:542–548
  46. Mizrahi EM , Kellaway P . Characterization and classification of neonatal seizures . Neurology . 1987;37:1837–1844
  47. Scher MS , Aso K , Beggarly ME , et al.   Electrographic seizures in preterm and full-term neonates (clinical correlates, associated brain lesions, and risk for neurological sequelae) . Pediatrics . 1993;91:128–134
  48. Boer HR , Gal P . Neonatal seizures (a survey of clinical practice) . Clin Pediatr . 1982;21:453–457
  49. Painter MR , Scher MS , Stein AD , et al.   Phenobarbital compared to phenytoin for the treatment of neonatal seizures . New Engl J Med . 1999;341:485–489
  50. Boylan GB , Rennie JM , Pressler RM , et al.   Phenobarbitone, neonatal seizures, and video-EEG . Arch Dis Child Fetal Neonatal Ed . 2002;86:F165–F170
  51. Boylan GB , Rennie JM , Chorley G , et al.   Second-line anticonvulsant treatment of neonatal seizures. A video-EEG monitoring study . Neurology . 2004;62:486–488
  52. Hall RT , Hall FK , Daily DK . High-dose phenobarbital therapy in term newborn infants with severe perinatal asphyxia (a randomized, prospective study with three-year follow-up) . J Pediatr . 1998;132:345–348
  53. Goldberg RN , Moscoso P , Bauer CR , et al.   Use of barbiturate therapy in severe perinatal asphyxia (a randomized controlled trial) . J Pediatr . 1986;109:851–856
  54. Drew JH , Kitchen WH . The effect of maternally administered drugs on bilirubin concentrations in the newborn infant . J Pediatr . 1976;89:657–661
  55. Sheth RD , Buckley DJ , Gutierrez AR , et al.   Midazolam in the treatment of refractory neonatal seizures . Clin Neuropharmacol . 1996;19:165–170
  56. Hellstrom-Westas L , Westgren U , Rosen I , et al.   Lidocaine for treatment of severe seizures in newborn infants. Clinical effects and cerebral electrical activity monitoring . Acta Paediatr Scand . 1988;77:79–84
  57. Rey E , Radvanyi-Bouvet MF , Bodiou C , et al.   Intravenous lidocaine in the treatment of convulsions in the neonatal period (monitoring plasma levels) . Ther Drug Monit . 1990;12:16–20
  58. Moran LR , Hossain T , Insoft RM . Neonatal seizures following lidocaine administration for elective circumcision . J Perinatol . 2004;24:395–396
  59. Resar LM , Helfaer MA . Recurrent seizures in a neonate after lidocaine administration . J Perinatol . 1998;18:193–195
  60. Barr PA , Buettiker VE , Antony JH . Efficacy of lamotrigine in refractory neonatal seizures . Pediatr Neurol . 1999;20:161–163
  61. Ohno M , Shimotsuji Y , Abe J , et al.   Zonisamide treatment of early infantile epileptic encephalopathy . Pediatr Neurol . 2000;23:341–344
  62. Baxter PS , Gardner-Medwin D , Barwick DD , et al.   Vigabatrin monotherapy in resistant neonatal seizures . Seizure . 1995;4:57–59
  63. Steinberg A , Shalev RS , Amir N . Valproic acid in neonatal status convulsivus . Brain Dev . 1986;8:278–279
  64. Hunt AD , Stokes J , McCrory WW , et al.   Pyridoxine dependency (report of a case of intractable convulsions in an infant controlled by pyridoxine) . Pediatrics . 1954;13:140–145
  65. Baxter P . Pyridoxine-dependent and pyridoxine-responsive seizures . Dev Med Child Neurol . 2001;43:416–420
  66. Gospe SM . Pyridoxine-dependent seizures (findings from recent studies pose new questions) . Pediatr Neurol . 2002;26:181–185
  67. Baxter P . Epidemiology of pyridoxine dependent and pyridoxine responsive seizures in the UK . Arch Dis Child . 1999;81:431–433
  68. Nabbout R , Soufflet C , Plouin P , et al.   Pyridoxine dependent epilepsy (a suggestive electroclinical pattern) . Arch Dis Child Fetal Neonatal Ed . 1999;81:F125–F129
  69. Bejsovec M , Kulenda Z , Ponca E . Familial intrauterine convulsions in pyridoxine dependency . Arch Dis Child . 1967;42:201–207
  70. Bass NE , Wyllie E , Cohen B , et al.   Pyridoxine-dependent epilepsy (the need for repeated pyridoxine trials and the risk of severe electrocerebral suppression with intravenous pyridoxine infusion) . J Child Neurol . 1996;11:422–424
  71. Kroll JS . Pyridoxine for neonatal seizures (an unexpected danger) . Dev Med Child Neurol . 1985;27:369–382
  72. Torres OA , Miller VS , Buist NM , et al.   Folinic acid-responsive neonatal seizures . J Child Neurol . 1999;14:529–532
  73. Wolf B , Heard GS , Weissbecker KA , et al.   Biotinidase deficiency (initial clinical features and rapid diagnosis) . Ann Neurol . 1985;18:614–617
  74. Perucca E . Pharmacological problems in the management of epilepsy in children . Seizure . 1995;4:139–143
  75. Leppik IE . Metabolism of antiepileptic medication (newborn to elderly) . Epilepsia . 1992;33(suppl 4):S32–S40
  76. Gilman JT . Developmental principles of antiepileptic drug therapy . J Child Neurol . 1994;9(suppl 1):S20–S25
  77. Bittigau P , Sifringer M , Genz K , et al.   Antiepileptic drugs and apoptotic neurodegeneration in the developing brain . Proc Natl Acad Sci U S A . 2002;99:15089–15094
  78. McBride MC , Laroia N , Guillet R . Electrographic seizures in neonates correlate with poor neurodevelopmental outcome . Neurology . 2000;55:506–514
  79. Legido A , Clancy RR , Berman PH . Neurological outcome after electroencephalographically proven neonatal seizures . Pediatrics . 1991;88:583–596
  80. Koh S , Tibayan FD , Simpson JN , et al.   NBQX or topiramate treatment after perinatal hypoxia-induced seizures prevents later increases in seizure-induced neuronal injury . Epilepsia . 2004;45:569–575
  81. Tandon P , Liu Z , Stafstrom CE , et al.   Long-term effects of excitatory amino acid antagonists NBQX and MK-801 on the developing brain . Dev Brain Res . 1996;95:256–262

PII: S1071-9091(05)00041-0

doi: 10.1016/j.spen.2005.03.004

Seminars in Pediatric Neurology
Volume 12, Issue 2 , Pages 97-105 , June 2005

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