Seminars in Pediatric Neurology
Volume 12, Issue 4 , Pages 222-228 , December 2005

Childhood Epilepsy, Attention Problems, and ADHD: Review and Practical Considerations

  • David W. Dunn, MD

      Affiliations

    • Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN.
    • Department of Neurology, Indiana University School of Medicine, Indianapolis, IN.
    • Corresponding Author InformationAddress reprint requests to David W. Dunn, MD, Department of Psychiatry, Indiana University School of Medicine, 702 Barnhill Drive, ROC 4300, Indianapolis, IN 46202.
  • ,
  • William G. Kronenberger, PhD

      Affiliations

    • Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN.

References 

  1. Dunn DW . Attention-deficit hyperactivity disorder, oppositional defiant disorder, and conduct disorder . In:  Ettinger AB ,  Kanner AM editor. Psychiatric Issues in Epilepsy . Philadelphia, PA: Lippincott Williams & Wilkins; 2001;p. 111–126
  2. Sánchez-Carpintero R , Neville BGR . Attentional ability in children with epilepsy . Epilepsia . 2003;44:1340–1349
  3. Tan M , Appleton R . Attention deficit and hyperactivity disorder, methylphenidate, and epilepsy . Arch Dis Child . 2005;90:57–59
  4. Schubert R . Attention deficit disorder and epilepsy . Pediatr Neurol . 2005;32:1–10
  5. McDermott S , Mani S , Krishnaswami S . A population-based analysis of specific behavior problems associated with childhood seizures . J Epilepsy . 1995;8:110–118
  6. Carlton-Ford S , Miller R , Brown M , et al.   Epilepsy and children’s social and psychological adjustment . J Health Soc Behav . 1995;36:285–301
  7. Davies S , Heyman I , Goodman R . A population survey of mental health problems in children with epilepsy . Dev Med Child Neurol . 2003;45:292–295
  8. Aman MG , Werry JS , Turbott SH . Behavior of children with seizure. Comparison with norms and effect of seizure type . J Nerv Ment Dis . 1992;180:124–129
  9. Hoare P , Kerley S . Psychosocial adjustment of children with chronic epilepsy and their families . Dev Med Child Neurol . 1991;33:201–215
  10. Hoare P , Mann H . Self-esteem and behavioural adjustment in children with epilepsy and children with diabetes . J Psychosom Res . 1994;38:859–869
  11. Schoenfeld J , Seidenberg M , Woodard A , et al.   Neuropsychological and behavioral status of children with complex partial seizures . Dev Med Child Neurol . 1999;41:724–731
  12. Austin JK , Harezlak J , Dunn DW , et al.   Behavior problems in children before first recognized seizures . Pediatrics . 2001;107:115–122
  13. Fastenau PS , Shen J , Dunn DW , et al.   Neuropsychological predictors of academic underachievement in pediatric epilepsy (moderating roles of demographic, seizure, and psychosocial variables) . Epilepsia . 2004;45:1261–1272
  14. Oostrom KJ , Schouten A , Kruitwagen CL , et al.   Attention deficits are not characteristic of schoolchildren with newly diagnosed idiopathic or cryptogenic epilepsy . Epilepsia . 2002;43:301–310
  15. Caplan R , Arbelle S , Magharious W , et al.   Psychopathology in pediatric complex partial and primary generalized epilepsy . Dev Med Child Neurol . 1998;40:805–811
  16. Caplan R , Siddarth P , Gurbani S , et al.   Psychopathology and pediatric complex partial seizures (seizure-related, cognitive, and linguistic variables) . Epilepsia . 2004;45:1273–1281
  17. Ott D , Caplan R , Guthrie D , et al.   Measures of psychopathology in children with complex partial seizures and primary generalized epilepsy with absence . J Am Acad Child Adolesc Psychiatry . 2001;40:907–914
  18. Semrud-Clikeman M , Wical B . Components of attention in children with complex partial seizures with and without ADHD . Epilepsia . 1999;40:211–215
  19. Dunn DW , Austin JK , Harezlak J , et al.   ADHD and epilepsy in childhood . Dev Med Child Neurol . 2003;45:50–54
  20. Thome-Souza S , Kuczynski E , Assumpção F , et al.   Which factors may play a pivotal role on determining the type of psychiatric disorder in children and adolescents with epilepsy? . Epilepsy Behav . 2004;5:988–994
  21. Stores G . School children with epilepsy at risk for learning and behaviour problems . Dev Med Child Neurol . 1978;20:502–508
  22. Stores G , Hart J , Piran N . Inattentiveness in school children with epilepsy . Epilepsia . 1978;19:169–175
  23. Hesdorffer DC , Ludvigsson P , Olafsson E , et al.   ADHD as a risk factor for incident unprovoked seizures and epilepsy in children . Arch Gen Psychiatry . 2004;61:731–736
  24. Ferrie CD , Madigan C , Tilling K , et al.   Adaptive and maladaptive behaviour in children with epileptic encephalopathy (correlation with cerebral glucose metabolism) . Dev Med Child Neurol . 1997;39:588–595
  25. Holdsworth L , Whitmore K . A study of children with epilepsy attending ordinary schools (their seizure patterns, progress and behaviour in school) . Dev Med Child Neurol . 1974;16:746–758
  26. Steffenburg S , Gillberg C , Steffenburg U . Psychiatric disorder in children and adolescents with mental retardation and active epilepsy . Arch Neurol . 1996;53:904–912
  27. Riikonen R , Amnell G . Psychiatric disorders in children with earlier infantile spasms . Dev Med Child Neurol . 1981;23:747–760
  28. Austin JK , Harezlak J , Dunn DW , et al.   Behavior problems in children before first recognized seizures . Pediatrics . 2001;107:115–122
  29. Sherman EMS , Armitage LL , Connolly MB , et al.   Behaviors symptomatic of ADHD in pediatric epilepsy (relationship to frontal lobe epileptiform abnormalities and other neurological predictors) . Epilepsia . 2000;41(suppl 7):191
  30. Hernandez MT , Sauerwein HC , Jambaque I , et al.   Attention, memory, and behavioral adjustment in children with frontal lobe epilepsy . Epilepsy Behav . 2003;4:522–536
  31. Piccirilli M , D’Alessandro P , Sciarma T , et al.   Attention problems in epilepsy (possible significance of the epileptiform focus) . Epilepsia . 1994;35:1091–1096
  32. Holtmann M , Becker K , Kentner-Figura B , et al.   Increased frequency of rolandic spikes in ADHD children . Epilepsia . 2003;44:1241–1244
  33. Duane DD . Increased frequency of rolandic spikes in ADHD children . Epilepsia . 2004;45:564–655
  34. D’Alessandro P , Piccirilli M , Tiacci C , et al.   Neuropsychological features of benign partial epilepsy in children . Ital J Neurol Sci . 1990;11:265–269
  35. Aldenkamp A , Arends J . The relative influence of epileptic EEG discharges, short nonconvulsive seizures and type of epilepsy on cognitive function . Epilepsia . 2004;45:54–63
  36. Marston D , Besag F , Binnie CD , et al.   Effects of transient cognitive impairment on psychological functioning of children with epilepsy (a therapeutic trial) . Dev Med Child Neurol . 1993;35:574–581
  37. Schmitz B . The effects of antiepileptic drugs on behaviour . In:  Trimble M ,  Schmitz B editor. The Neuropsychiatry of Epilepsy . Cambridge: Cambridge University Press; 2002;p. 241–255
  38. Loring DW , Meador KJ . Cognitive side effects of antiepileptic drugs in children . Neurology . 2004;62:872–877
  39. Borgatti R , Piccinelli P , Montirossa R , et al.   Study of attentional processes in children with idiopathic epilepsy by Conners’ continuous performance test . J Child Neurol . 2004;19:509–515
  40. Noeker M , Haverkamp F . Neuropsychological deficiencies as a mediator between CNS dysfunction and inattentive behaviour in childhood epilepsy . Dev Med Child Neurol . 2003;45:717–718
  41. The MTA Cooperative Group . A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder . Arch Gen Psychiatry . 1999;56:1073–1086
  42. Becker DA , Fennell EB , Carney PR . Sleep disturbance in children with epilepsy . Epilepsy Behav . 2003;4:651–658
  43. Dunn DW , Kronenberger WG . Attention-deficit/hyperactivity disorder in children and adolescents . Neurol Clin North Am . 2003;21:933–940
  44. American Academy of Child and Adolescent Psychiatry . Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults . J Am Acad Child Adolesc Psychiatry . 2002;41(suppl 2):26S–49S
  45. American Academy of Pediatrics Committee on Quality Improvement Subcommittee on Attention-Deficit/Hyperactivity Disorder . Clinical practice guideline (treatment of the school-aged child with attention-deficit/hyperactivity disorder) . Pediatrics . 2001;108:1033–1044
  46. Feldman H , Crumrine P , Handen BL , et al.   Methylphenidate in children with seizures and attention deficit disorder . Am J Dis Child . 1989;143:1081–1086
  47. Gross-Tsur V , Manor O , van der Meere J , et al.   Epilepsy and attention deficit hyperactivity disorder (is methylphenidate safe and effective?) . J Pediatr . 1997;130:670–674
  48. Gucuyener K , Erdemoglu AK , Senol S , et al.   Use of methylphenidate for attention-deficit hyperactivity disorder in patients with epilepsy or electroencephalographic abnormalities . J Child Neurol . 2003;18:109–112
  49. Gonzalez-Heydrich J , Hsin O , Hickory M , et al.   In: Comparisons of response to stimulant preparations in pediatric epilepsy. . 2004;p. 107–108 AACAP 2004 Scientific Proceedings, Oct. 19-24, Washington DC
  50. Millichap JG . Attention deficit-hyperactivity disorder and the electroencephalogram . Epilepsy Behav . 2000;1:453
  51. Richer LP , Shevell MI , Rosenblatt BR . Epileptiform abnormalities in children with attention deficit hyperactivity disorder . Pediatr Neurol . 2002;26:125–129
  52. Holtmann M , Becker K , Kentner-Figura B , et al.   Increased frequency of rolandic spikes in ADHD children . Epilepsia . 2003;44:1241–1244
  53. Aydin K , Okuyaz C , Serdaroglu A , et al.   Utility of electroencephalography in the evaluation of common neurologic conditions in children . J Child Neurol . 2003;18:394–396
  54. Hemmer SA , Pasternak JF , Zecker SG , et al.   Stimulant therapy and seizure risk in children with ADHD . Pediatr Neurol . 2001;24:99–102
  55. Hughes JR , DeLeo AJ , Melyn MA . The electroencephalogram in attention deficit-hyperactivity disorder (emphasis on epileptiform discharges) . Epilepsy Behav . 2000;1:271–277
  56. Cavazzuti GB , Cappella L , Nalin A . Longitudinal study of epileptiform EEG patterns in normal children . Epilepsia . 1980;21:43–55
  57. Michelson D , Allen AJ , Busner J , et al.   Once-daily atomoxetine treatment for children and adolescents with attention deficit hyperactivity disorder (a randomized, placebo-controlled study) . Am J Psychiatry . 2002;159:1896–1901
  58. Alldredge BK . Seizure risk associated with psychotropic drugs (clinical and pharmacokinetic considerations) . Neurology . 1999;53(suppl 2):S68–S75
  59. Bulteau C , Jambaque I , Viguier D , et al.   Epileptic syndromes, cognitive assessment and school placement (a study of 251 children) . Dev Med Child Neurol . 2000;42:319–327
  60. Zelnik N , Sa’adi L , Silman-Stolar Z , et al.   Seizure control and educational outcome in childhood-onset epilepsy . J Child Neurol . 2001;16:820–824
  61. Nolan MA , Redoblado MA , Lah S , et al.   Intelligence in childhood epilepsy syndromes . Epilepsy Res . 2003;53:139–150
  62. Barkley RA . Attention Deficit Hyperactivity Disorder (A Handbook for Diagnosis and Treatment) . (ed 2). New York, NY: Guilford; 1998;
  63. Williams J , Phillips T , Griebel ML , et al.   Factors associated with academic achievement in children with controlled epilepsy . Epilepsy Behav . 2001;2:217–223
  64. Kronenberger WG , Meyer RG . The Child Clinician’s Handbook . Boston: Allyn & Bacon; 2001;
  65. Spafford CS , Grosser GS . Dyslexia (Research and Resource Guide) . Boston, MA: Allyn & Bacon; 1996;
  66. Eden GF , Jones KM , Cappell K , et al.   Neural changes following remediation in adult developmental dyslexia . Neuron . 2004;44:411–422
  67. Barkley RA . Taking Charge of ADHD . New York, NY: Guilford; 2000; (revised edition)
  68. Phelan TW . All about Attention Deficit Disorder . Glen Ellyn, IL: Child Management; 1996;

PII: S1071-9091(05)00082-3

doi: 10.1016/j.spen.2005.12.004

Seminars in Pediatric Neurology
Volume 12, Issue 4 , Pages 222-228 , December 2005