Seminars in Pediatric Neurology
Volume 13, Issue 1 , Pages 8-20, March 2006

Cognitive Profile of Neurofibromatosis Type 1

  • Terry M. Levine, MS

      Affiliations

    • Kennedy Krieger Institute, Department of Developmental Cognitive Neurology, Baltimore, MD
    • ,
  • April Materek, MS

      Affiliations

    • Kennedy Krieger Institute, Department of Developmental Cognitive Neurology, Baltimore, MD
    • ,
  • Jessica Abel, BS

      Affiliations

    • Kennedy Krieger Institute, Department of Developmental Cognitive Neurology, Baltimore, MD
    • ,
  • Madeline O’Donnell

      Affiliations

    • Bates College, Lewiston, ME
    • ,
  • Laurie E. Cutting, PhD

      Affiliations

    • Kennedy Krieger Institute, Department of Developmental Cognitive Neurology, Baltimore, MD
    • Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD
    • Department of Education, Johns Hopkins University, Baltimore, MD
    • Corresponding Author InformationAddress reprint requests to Laurie E. Cutting, PhD, Kennedy Krieger, Department of Developmental Cognitive Neurology, 707 North Broadway, Baltimore, MD 21205

General consensus has yet to be reached with regard to the exact cognitive profile of children with neurofibromatosis type 1 (NF1). The current overview seeks to provide a more comprehensive review of the literature by examining studies that have specifically compared individuals with NF1 to siblings, controls, and/or norms. We also examined results of studies that compared individuals with NF1 with various manifestations to each other. Consistent with previous reviews, no clear cognitive profile emerged; however, greater insight into patterns was obtained. Additionally, future directions for research on NF1 were suggested.

Keywords:  Neurofibromatosis type 1 , children , learning disabilities , cognitive deficts

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 Supported in part a grant from the U.S. Congressionally Directed Materiel and Medical Command (DAMD17-00-1-0548).

PII: S1071-9091(06)00010-6

doi:10.1016/j.spen.2006.01.006

Seminars in Pediatric Neurology
Volume 13, Issue 1 , Pages 8-20, March 2006

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