Seminars in Pediatric Neurology
Volume 13, Issue 1 , Pages 37-42, March 2006

The Neurobiology of Tuberous Sclerosis Complex

  • Kevin C. Ess, MD, PhD

      Affiliations

    • Departments of Neurology and Pediatrics, Washington University School of Medicine, St Louis, MO
    • Division of Pediatric and Developmental Neurology and the Pediatric Epilepsy Center, Tuberous Sclerosis Clinic, St Louis Children’s Hospital, St Louis, MO.
    • Corresponding Author InformationAddress reprint requests to Kevin C. Ess, MD, PhD, Vanderbilt University, Department of Neurology, 2311 Pierce Avenue, Nashville, TN 37232-3375.

Tuberous sclerosis complex (TSC) is a multiorgan genetic disease caused by inactivation of either the TSC1 or TSC2 genes. The disorder typically has profound neurologic involvement and often presents early in life with epilepsy, developmental delay, mental retardation, and autism. These features are generally accepted to result from structural brain abnormalities that are found in patients with TSC. Although much progress has recently been made in discerning the function(s) of the TSC genes, many questions remain as to the role of these genes in brain development and homeostasis. This review will summarize recent progress and suggest future avenues of basic science research.

Keywords:  tuber , epilepsy , cortical malformation , autism

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PII: S1071-9091(06)00013-1

doi:10.1016/j.spen.2006.01.009

Seminars in Pediatric Neurology
Volume 13, Issue 1 , Pages 37-42, March 2006

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