Seminars in Pediatric Neurology
Volume 13, Issue 3 , Pages 149-157 , September 2006

Ferroportin in the Postnatal Rat Brain: Implications for Axonal Transport and Neuronal Export of Iron

  • Torben Moos, MD, PhD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Torben Moos, Department of Medical Anatomy, The Panum Institute, 18.2, University of Copenhagen, 3 Blegdamsvej, DK-2200 Copenhagen N, Denmark.
    • ,
  • Thomas Rosengren Nielsen, MS

References 

  1. Moos T. Immunohistochemical localization of intraneuronal transferrin receptor immunoreactivity in the adult mouse central nervous system. J Comp Neurol. 1996;374:675–692
  2. Moos T, Oates PS, Morgan EH. Expression of the neuronal transferrin receptor is age dependent and susceptible to iron deficiency. J Comp Neurol. 1998;398:420–430
  3. Taylor EM, Crowe A, Morgan EH. Transferrin and iron uptake by the brain: Effects of altered iron status. J Neurochem. 1991;57:1584–1592
  4. Johanson CE. Ontogeny and phylogeny of the blood-brain barrier. In:  Neuwelt E editors. Implications of the Blood-Brain Barrier and Its Manipulation. New York, NY: Plenum; 1989;p. 157–198
  5. Moos T, Morgan EH. The metabolism of neuronal iron and its pathogenic role in neurological disease: Review. Ann NY Acad Sci. 2004;1012:14–26
  6. Zecca L, Youdim MB, Riederer P, et al. Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci. 2004;5:863–873
  7. Wrigglesworth JM, Baum H. Iron-dependent enzymes in the brain. In:  Youdim MBH editors. Brain Iron: Neurochemical and Behavioral Aspects. Philadelphia, PA: Taylor and Francis; 1988;p. 25–66
  8. Moos T, Morgan EH. The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain. J Neurochem. 2004;88:233–245
  9. Moos T, Morgan EH. Kinetics and distribution of [59Fe-125I]transferrin injected into the ventricular system of the rat. Brain Res. 1998;790:115–128
  10. Hansen TM, Nielsen H, Bernth N, et al. Expression of ferritin protein and subunit mRNAs in normal and iron deficient rat brain. Mol Brain Res. 1999;65:186–197
  11. Benkovic SA, Connor JR. Ferritin, transferrin and iron in selected regions of the adult and aged rat brain. J Comp Neurol. 1993;338:97–113
  12. Abboud S, Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem. 2000;275:19906–19912
  13. Donovan A, Brownlie A, Zhou Y, et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000;403:776–781
  14. Burdo JR, Menzies SL, Simpson IA, et al. Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat. J Neurosci Res. 2001;66:1198–1207
  15. Wu LJ, Leenders AG, Cooperman S, et al. Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier. Brain Res. 2004;1001:108–117
  16. Donovan A, Lima CA, Pinkus JL, et al. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 2005;1:191–200
  17. Delaby C, Pilard N, Goncalves AS, et al. Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin. Blood. 2005;106:3979–3984
  18. Zhang AS, Xiong S, Tsukamoto H, et al. Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes. Blood. 2004;103:1509–1514
  19. Dwork AJ. Effects of diet and development upon the uptake and distribution of cerebral iron. J Neurol Sci. 1995;134(Suppl):45–51
  20. Moos T, Morgan EH. A morphological study of the developmentally regulated transport of iron into the brain. Dev Neurosci. 2002;24:99–105
  21. Dallman PR, Spirito RA. Brain iron in the rat: Extremely slow turnover in normal rats may explain long-lasting effects of early iron deficiency. J Nutr. 1977;107:1075–1081
  22. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. New York, NY: Academic Press; 1986;
  23. Moos T. Developmental profile of non-heme iron distribution in the rat brain during ontogenesis. Dev Brain Res. 1995;87:203–213
  24. Aguirre P, Mena N, Tapia V, et al. Iron homeostasis in neuronal cells: a role for IREG1. BMC Neurosci. 2005;6:3
  25. Jiang DH, Ke Y, Cheng YZ, et al. Distribution of ferroportin1 protein in different regions of developing rat brain. Dev Neurosci. 2002;24:94–98
  26. Dwork AJ, Lawler G, Zybert PA, et al. An autoradiographic study of the uptake and distribution of iron by the brain of the young rat. Brain Res. 1990;518:31–39
  27. Groenewegen HJ, Ahlenius S, Haber SN, et al. Cytoarchitecture, fiber connections, and some histochemical aspects of the interpeduncular nucleus in the rat. J Comp Neurol. 1986;249:65–102
  28. Lecourtier L, Neijt HC, Kelly PH. Habenula lesions cause impaired cognitive performance in rats: Implications for schizophrenia. Eur J Neurosci. 2004;19:2551–2560
  29. Stainier DY, Gilbert W. Neuronal differentiation and maturation in the mouse trigeminal sensory system, in vivo and in vitro. J Comp Neurol. 1991;311:300–312
  30. Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306:2090–2093
  31. Gregory A, Hayflick SJ. Neurodegeneration with brain iron accumulation. Folia Neuropathol. 2005;43:286–296
  32. Lee DW, Andersen JK, Kaur D. Iron dysregulation and neurodegeneration: the molecular connection. Mol Interv. 2006;6:89–97

 Supported by grants from Dansk Parkinsonforening, Fonden til Lægevidenskabens Fremme, Carlsberg Fonden, and Lundbeck Fonden (T Moos). Thomas Rosengren Nielsen is a recipient of a “Body and Mind” scholarship from the University of Copenhagen.

PII: S1071-9091(06)00102-1

doi: 10.1016/j.spen.2006.08.003

Seminars in Pediatric Neurology
Volume 13, Issue 3 , Pages 149-157 , September 2006

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