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Seminars in Pediatric Neurology
Volume 14, Issue 2
, Pages 51-59
, June 2007
Hypothalamic Hamartoma: Basic Mechanisms of Intrinsic Epileptogenesis
References
- Cellular and molecular mechanisms of epilepsy in the human brain. Prog Neurobiol. 2005;77:166–200
- Epileptogenesis in pediatric cortical dysplasia: The dysmature cerebral developmental hypothesis. Epilepsy Behav. 2006;9:219–235
- The hypothalamic hamartoma: A model of subcortical epileptogenesis and encephalopathy. Semin Pediatr Neurol. 2005;12:119–131
- Crises dacrystiques et hamartome hypothalamique (A propos d’une observation video-stereo-EEG). Epilepsies. 1994;6:259–279
- Intrinsic epileptogenesis of hypothalamic hamartomas in gelastic epilepsy. Ann Neurol. 1997;42:60–67
- . Human epileptogenesis and hypothalamic hamartomas: New lessons from an experiment of nature. Epilepsia. 1997;38:1–3
- Hypothalamic hamartoma and seizures: A treatable epileptic encephalopathy. Epilepsia. 2003;44:969–973
- Gelastic seizures and hypothalamic hamartomas: Evaluation of patients undergoing chronic intracranial EEG monitoring and outcome of surgical treatment. Neurology. 1993;43:747–750
- Role of the hypothalamic hamartoma in the genesis of gelastic fits (a video-stereo-EEG study). Electroencephalogr Clin Neurophysiol. 1995;95:154–160
- Hypothalamic hamartomas and gelastic epilepsy: A spectroscopic study. Neurology. 1998;51:1046–1050
- Stereotaxy for hypothalamic hamartoma with intractable gelastic seizures: Technical case report. Neurosurgery. 1999;44:1347–1350
- Resection of the lesion in patients with hypothalamic hamartoma and catastrophic epilepsy. Neurology. 2002;58:1338–1347
- From hypothalamic hamartoma to cortex: What can be learnt (sic) from depth recordings and stimulation. Epileptic Disord. 2003;5:205–217
- Epilepsy syndromes associated with hypothalamic hamartomas. Seizure. 2007;16:50–58
- Interictal spike EEG source analysis in hypothalamic hamartoma epilepsy. Clin Neurophysiol. 2002;113:1961–1969
- Ictal laughter associated with paroxysmal hypothalamopituitary dysfunction. Epilepsia. 1997;38:114–117
- . Neuropathology of tuberous sclerosis. Brain Dev. 2001;23:508–515
- Morphological and electrophysiological characterization of abnormal cell types in pediatric cortical dysplasia. J Neurosci Res. 2003;72:472–486
- Terminology and classification of the cortical dysplasias. Neurology. 2004;62:S2–S8
- Mechanisms of epileptogenicity in cortical dysplasias. Neurology. 2004;62:S9–S13
- . Giant cells: Contradiction to two-hit model of tuber formation?. Cell Mol Neurobiol. 2005;25:795–805
- The histopathology of hypothalamic hamartomas: Study of 57 cases. J Neuropathol Exp Neurol. 2007;66:131-41
- . Clonally related cortical cells show several migration patterns. Science. 1988;241:1342–1345
- Contralateral hemimicrencephaly and clinical-pathological correlations in children with hemimegalencephaly. Brain. 2006;129:352–365
- Electrophysiological properties of neurons in intact brain slices from surgically-resected human hypothalamic hamartomas. Epilepsia. 2005;46(suppl 8):275–276
- . Cerebral cortical dysplasia: Giant neurons show potential for increased excitation and axonal plasticity. Dev Neurosci. 1999;21:260–270
- Epileptogenicity correlated with increased N-methyl-D-aspartate receptor subunit NR2A/B in human focal cortical dysplasia. Epilepsia. 2000;41:971–976
- Electrophysiological properties of human hypothalamic hamartomas. Ann Neurol. 2005;58:371–382
- A planar multielectrode array analysis of resected human hypothalamic hamartoma tissue. Epilepsia. 2007;47(suppl 4):280
- . Models and mechanisms of experimental epilepsies. Epilepsia. 2003;44(suppl 12):44–50
- . Neurophysiology of epilepsy. In: Swaiman K, Ashwal S, Ferreiro D editor. Pediatric Neurology: Principles and Practice. (ed 4).. New York, NY: Elsevier; 2006;
- Spontaneous sharp waves in human neocortical slices excised from epileptic patients. Brain. 1998;121:1073–1087
- . Human epileptic neurons studied in vitro. Brain Res. 1981;210:323–333
- Hyperexcitability associated with localizable lesions in epileptic patients. Brain Res. 1992;587:158–163
- . GABA as an inhibitory neurotransmitter in human cerebral cortex. J Neurophysiol. 1989;62:1018–1027
- Optical monitoring of neuronal activity during spontaneous sharp waves in chronically epileptic human neocortical tissue. J Neurophysiol. 2000;84:2161–2165
- . Intracellular study of human epileptic cortex: In vitro maintenance of epileptiform activity?. Science. 1984;223:709–712
- . Microphysiology of human cerebral cortex studied in vitro. Brain Res. 1976;115:497–500
- Seizure-like discharges induced by lowering [Mg2+]o in the human epileptogenic neocortex maintained in vitro. Brain Res. 1987;417:199–203
- . Convergence and divergence of neurotransmitter action in human cerebral cortex. Proc Natl Acad Sci U S A. 1989;86:8098–8102
- . Spontaneous rhythmic synchronous activity in epileptic human and normal monkey temporal lobe. Epilepsia. 1986;27:523–533
- Are cytomegalic neurons and balloon cells generators of epileptic activity in pediatric cortical dysplasia?. Epilepsia. 2005;46:82–88
- Induced expression of NMDAR2 proteins and differential expression of NMDAR1 splice variants in dysplastic neurons of human epileptic neocortex. J Neuropathol Exp Neurol. 1998;57:47–62
- Selective alterations in glutamate and GABA receptor subunit mRNA expression in dysplastic neurons and giant cells of cortical tubers. Ann Neurol. 2001;49:67–78
- Paired pulse suppression and facilitation in human epileptogenic hippocampal formation. Epilepsy Res. 1998;31:211–230
- . Increased NMDA responses and dendritic degeneration in human epileptic hippocampal neurons in slices. Neurosci Lett. 1991;132:212–216
- . Deelopmental changes in NMDA-induced intrinsic optical signals in the hippocampal dentate gyrus of children with medically intractable seizures. Dev Neurosci. 1999;21:215–222
- Synaptic plasticity in the human dentate gyrus. J Neurosci. 2000;20:7080–7086
- . Cellular electrophysiology of human epilepsy. Epilepsy Res. 1994;17:185–192
- Glutamate currents in morphologically identified human dentate granule cells in temporal lobe epilepsy. J Neurophysiol. 1997;77:3355–3369
- Intrinsic excitability, synaptic potentials, and short-term plasticity in human epileptic neocortex. J Neurosci Res. 2005;80:715–726
- GABA and its receptors in epilepsy. Adv Exp Med Biol. 2004;548:92–103
- . Molecular biology and ontogeny of gamma-aminobutyric acid (GABA) receptors in the mammalian central nervous system. J Child Neurol. 2003;18:39–48
- . Physiologic and morphologic characteristics of granule cells from human epileptic hippocampus. Epilepsia. 1991;32:46
- . Depth electrode studies and intracellular dentate granule cell recordings in temporal lobe epilepsy. Ann Neurol. 1995;38:778–787
- Epileptiform synchronization in the human dysplastic cortex. Epileptic Disord. 2003;5:S45–S50
- Bicuculline-induced epileptogenesis in the human neocortex maintained in vitro. Exp Brain Res. 1991;83:329–339
- . Emergent properties of CNS neuronal networks as targets for pharmacology: Application to anticonvulsant drug action. Prog Neurobiol. 2004;72:55–85
- . Multiple facets of GABAergic neurons and synapses: Multiple fates of GABA signalling in epilepsies. Trends Neurosci. 2005;28:108–115
- GABAA receptor-dependent synchronization leads to ictogenesis in the human dysplastic cortex. Brain. 2004;127:1626–1640
- Mossy fiber synaptic reorganization in the epileptic human temporal lobe. Ann Neurol. 1989;26:321–330
- . Nonsynaptic mechanisms in seizures and epileptogenesis: Targets for clinical management?. In: Rho JM, Sankar R, Cavazos JE editor. Epilepsy, Scientific Foundations of Clinical Practice. New York, NY: Marcel Dekker; 2004;p. 91–105
- . Role of the depolarizing GABA response in epilepsy. Adv Exp Med Biol. 2004;548:104–109
- . Excitatory actions of GABA during development: The nature of the nurture. Nat Rev Neurosci. 2002;3:728–739
Supported in part by the Barrow Neurological Foundation and Women’s Board (JFK), CURE Research grant (JMR), and the National Institutes of Health grants NINDS NS056104 (JW) and NS044846 (JMR).
PII: S1071-9091(07)00021-6
doi: 10.1016/j.spen.2007.03.002
© 2007 Elsevier Inc. All rights reserved.
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Seminars in Pediatric Neurology
Volume 14, Issue 2
, Pages 51-59
, June 2007
