Seminars in Pediatric Neurology
Volume 14, Issue 2 , Pages 65-72 , June 2007

Cognitive and Behavioral Dysfunction in Children With Hypothalamic Hamartoma and Epilepsy

  • George P. Prigatano, PhD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to George P. Prigatano, PhD, Clinical Neuropsychology, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, 222 West Thomas Rd, Suite 315, Phoenix, AZ 85013.

References 

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  2. Saper CB. The hypothalamus. In:  Paxinos G,  Mai JK editor. The Human Nervous System. Amsterdam: Elsevier; 2004;p. 513–550
  3. Nguyen D, Singh S, Zaatreh M, et al. Hypothalamic hamartomas: Seven cases and review of the literature. Epilepsy Behav. 2003;4:246–258
  4. Valdueza JM, Cristante L, Dammann O, et al. Hypothalamic hamartomas: With special reference to gelastic epilepsy and surgery. Neurosurgery. 1994;34:949–958
  5. Kerrigan JF, Ng Y, Chung S, et al. The hypothalamic hamartoma: A model of subcortical epileptogenesis and encephalopathy. Semin Pediatr Neurol. 2005;12:119–131
  6. Berkovic SF, Andermann F, Melanson D, et al. Hypothalamic hamartomas and ictal laughter: Evolution of a characteristic epileptic syndrome and diagnostic value of magnetic resonance imaging. Ann Neurol. 1988;23:429–439
  7. Arita K, Ikawa F, Kurisu K, et al. The relationship between magnetic resonance imaging findings and clinical manifestations of hypothalamic hamartoma. J Neurosurg. 1999;91:212–220
  8. Freeman JL, Coleman LT, Wellard RM, et al. MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: Analysis of 72 cases. Am J Neuroradiol. 2004;25:450–462
  9. Deonna T, Ziegler AL. Hypothalamic hamartoma, precocious puberty and gelastic seizures: A special model of “epileptic” developmental disorder. Epileptic Disord. 2000;2:33–37
  10. Frattali DM, Liow K, Craig GH, et al. Cognitive deficits in children with gelastic seizures and hypothalamic hamartoma. Neurology. 2001;51:43-36
  11. Striano S, Striano P, Sarappa C, et al. The clinical spectrum and natural history of gelastic epilepsy-hypothalamic hamartoma syndrome. Seizure. 2005;14:232–239
  12. Quiske A, Frings L, Wagner K, et al. Cognitive functions in juvenile and adult patients with gelastic epilepsy due to hypothalamic hamartoma. Epilepsia. 2006;47:153–158
  13. Prigatano GP, Wethe JV, Rekate HL, et al: Neuropsychological dysfunction in patients with hypothalamic hamartomas and refractory epilepsy. Am Epilepsy Soc (Abstract, 2006). Available at: http://www.aesnet.org/Visitors/AnnualMeeting/Abstractsnew/dsp_Abstract.cfm?id=320. Accessed May 9, 2007
  14. Weissenberger AA, Dell ML, Liow K, et al. Aggression and psychiatric comorbidity in children with hypothalamic hamartomas and their unaffected siblings. J Am Acad Child Adolesc Psychiatry. 2001;40:696–703
  15. Savard G, Bhanji NH, Dubeau F, et al. Psychiatric aspects of patients with hypothalamic hamartoma and epilepsy. Epileptic Dis. 2003;5:229–234
  16. Prigatano GP, Gray J, Wethe JV: Psychiatric diagnoses applied to children and adults with HH and refractory epilepsy. Barrow Quarterly 22:4-9
  17. Lesser RP, Luders H, Wyllie E, et al. Mental deterioration in epilepsy. Epilepsia. 1986;27(suppl 2):S105–S123
  18. Trimble MR, Thompson PJ. Neuropsychological aspects of epilepsy. In:  Grant I,  Adams KM editor. Neuropsychological Assessment of Neuropsychiatric Disorders. New York: Oxford University Press; 1986;p. 321–346
  19. Herman BP, Seidenberg M, Bell B. The neurodevelopmental impact of childhood onset temporal lobe epilepsy on brain structure and function and the risk of progressive cognitive effects. In:  Sutula T,  Pitkanen A editor. Progress in Brain Research. vol 135:Amsterdam: Elsevier Science BV; 2002;p. 429–438
  20. Trimble MR. Cognitive hazards of seizure disorders. Epilepsia. 1988;29:S19–S24

PII: S1071-9091(07)00023-X

doi: 10.1016/j.spen.2007.03.004

Seminars in Pediatric Neurology
Volume 14, Issue 2 , Pages 65-72 , June 2007

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