Seminars in Pediatric Neurology
Volume 14, Issue 2 , Pages 80-87 , June 2007

Treatment Options for Gelastic Epilepsy Due to Hypothalamic Hamartoma: Interstitial Radiosurgery

  • Andreas Schulze-Bonhage, MD, PhD

      Affiliations

    • Epilepsy Centre, University Hospital Freiburg, Freiburg, Germany.
    • Corresponding Author InformationAddress reprint requests to Andreas Schulze-Bonhage, MD, PhD, Epilepsy Centre, Neurocenter, University Hospital Freiburg, Breisacher Str. 64, D-79,106 Freiburg, Germany.
    • ,
  • Christoph Ostertag, MD, PhD

      Affiliations

    • Department of Stereotactic Neurosurgery, University Hospital Freiburg, Freiburg, Germany.

References 

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  2. Ostertag CB. Brachytherapy-interstitial implant radiosurgery. Acta Neurochir Suppl (Wien). 1993;58:79–84
  3. Ostertag CB. Radiation implants for low-grade gliomas. Tech Neurosurg. 1996;2:174–182
  4. Kreth FW, Faist M, Rossner R, et al. The risk of interstitial radiotherapy of low-grade gliomas. Radiother Oncol. 1997;43:253–260
  5. Freeman JL, Coleman LT, Wellard RM, et al. MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: Analysis of 72 cases. Am J Neuroradiol. 2004;25:450–462
  6. Engel J, Rasmussen TB. Outcome with respect to seizures. In:  Engel J editors. Surgical Treatment of Epilepsies. New York: Raven Press; 1993;p. 609–621
  7. Frattali CM, Liow K, Craig GH, et al. Cognitive deficits in children with gelastic seizures and hypothalamic hamartoma. Neurology. 2001;57:43–46
  8. Quiske A, Frings L, Wagner K, et al. Cognitive functions in juvenile and adult patients with gelastic epilepsy due to hypothalamic hamartoma. Epilepsia. 2006;47:153–158
  9. Quiske A, Unterrainer J, Wagner K, et al. Assessment of cognitive functions before and after stereotactic interstitial radiosurgery of hypothalamic hamartomas in patients with gelastic seizures. Epilepsy Behav. 2007;10:486–494
  10. Schulze-Bonhage A, Quiske A, Homberg V, et al. Effect of interstitial stereotactic radiosurgery on behavior and subjective handicap of epilepsy in patients with gelastic epilepsy. Epilepsy Behav. 2004;5:94–101
  11. Regis J, Scavarda D, Tamura M, et al. Epilepsy related to hypothalamic hamartomas: Surgical management with special reference to gamma knife surgery. Childs Nerv Syst. 2006;22:881–895
  12. Mathieu D, Kondziolka D, Niranjan A, et al. Gamma knife radiosurgery for refractory epilepsy caused by hypothalamic hamartomas. Stereotact Funct Neurosurg. 2006;84:82–87
  13. Harvey AS, Freeman JL, Berkovic SF, et al. Transcallosal resection of hypothalamic hamartomas in patients with intractable epilepsy. Epileptic Disord. 2003;5:257–265
  14. Ng YT, Rekate HL, Prenger EC, et al. Transcallosal resection of hypothalamic hamartoma for intractable epilepsy. Epilepsia. 2006;47:1192–1202
  15. Schulze-Bonhage A, Ostertag CH. Secondary hippocampal epilepgotenesis in gelastic epilepsy. Epilepsia. 2005;46:378;(suppl 6, abstr)
  16. Freeman JM, Harvey AS, Rosenfeld JV, et al. Generalized epilepsy in hypothalamic hamartoma. Neurology. 2003;60:762–767
  17. Delalande O, Fohlen M. Disconnecting surgical treatment of hypothalamic hamartoma in children and adults with refractory epilepsy and proposal of a new classification. Neurol Med Chir (Tokyo). 2003;43:61–68
  18. Boudreau EA, Liow K, Frattali CM, et al. Hypothalamic hamartomas and seizures: Distinct natural history of isolated and Pallister-Hall syndrome cases. Epilepsia. 2005;46:42–47
  19. Delalande OR, Fohlen MJ, Jalin , et al. Surgical treatment of epilepsy due to hypothalamic hamartoma: Technique and preliminary results in five cases. [Abstract] Epilepsia. 1998;39(suppl 6):90–91
  20. Palmini A, Chandler C, Andermann F, et al. Resection of the lesion in patients with hypothalamic hamartomas and catastrophic epilepsy. Neurology. 2002;58:1338–1347
  21. Rosenfeld JV, Harvey AS, Wrennall J, et al. Resection of hypothalamic hamartomas, with control of seizures, in children with gelastic epilepsy. Neurosurgery. 2001;48:108–118
  22. Kahane P, Ryvlin P, Hoffmann D, et al. From hypothalamic hamartoma to cortex: What can be learnt from depth recordings and stimulation?. Epileptic Disord. 2003;5:205–217
  23. Schulze-Bonhage A, Homberg V, Trippel M, et al. Interstitial radiosurgery in the treatment of gelastic epilepsy due to hypothalamic hamartomas. Neurology. 2004;62:644–647

PII: S1071-9091(07)00025-3

doi: 10.1016/j.spen.2007.03.006

Seminars in Pediatric Neurology
Volume 14, Issue 2 , Pages 80-87 , June 2007

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