Seminars in Pediatric Neurology
Volume 14, Issue 2 , Pages 88-98 , June 2007

Hypothalamic Hamartoma Treatment: Surgical Resection With the Transcallosal Approach

  • Jeffrey V. Rosenfeld, MD, MS, FRACS, FRCS(Ed), FACS

      Affiliations

    • Departments of Neurosurgery and Surgery, The Alfred Hospital and Monash University, Victoria, Australia.
    • Corresponding Author InformationAddress reprint requests to Professor Jeffrey V. Rosenfeld, MD, MS, FRACS, FRCS(Ed), FACS, Department of Surgery, Central and Eastern Clinical School, Monash University, The Alfred Hospital, Commercial Road, Prahran, Victoria, Australia 3181.
  • ,
  • Iman Feiz-Erfan, MD

      Affiliations

    • Department of Neurosurgery, The Barrow Neurological Institute, Phoenix, AZ.

References 

  1. Rosenfeld JV, Harvey AS. Hypothalamic hamartoma. In:  Tonn JC,  Westphal M,  Rutka JT, et al. editor. Neuro-Oncology of CNS Tumors. New York: Springer-Verlag; 2006;p. 443–451
  2. Brandberg G, Raininko R, Eeg-Olofsson O. Hypothalamic hamartoma with gelastic seizures in Swedish children and adolescents. Eur J Pediatr Neurol. 2004;6:35–44
  3. Freeman JL, Coleman LT, Wellard RM, et al. MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: Analysis of 72 cases. Am J Neuroradiol. 2004;25:450–462
  4. Kerrigan JF, Ng Y-T, Chung S, et al. The hypothalamic hamartoma: A model of subcortical epileptogenesis and encephalopathy. Semin Pediatr Neurol. 2005;12:119–131
  5. Kang S, Graham JM, Olney AH, et al. Gli 3 frameshift mutaions cause autosomal dominant Pallister-Hall syndrome. Nat Genet. 1997;15:266–268
  6. Munari C, Kahane P, Francione S, et al. Role of hypothalamic hamartoma in the generation of gelastic fits (a video-stereo-EEG study). Electroencephalogr Clin Neurophysiol. 1995;95:154–160
  7. Kuzniecky R, Guthrie B, Mountz J, et al. Intrinsic epileptogenicity of hypothalamic hamartomas in gelastic epilepsy. Ann Neurol. 1997;42:60–67
  8. Berkovic SF, Kuzniecky RI, Andermann F. Human epileptogenesis and hypothalamic hamartomas: New lessons from an experiment of nature. Epilepsia. 1997;38:1–3
  9. Berkovic SF, Arzimanoglou A, Kuzniecky R, et al. Hypothalamic hamartoma and seizures: a treatable epileptic encephalopathy. Epilepsia. 2003;44:969–973
  10. Harvey AS, Freeman JL, Berkovic SF, et al. Transcallosal resection of hypothalamic hamartomas in patients with intractable epilepsy. Epileptic Disord. 2003;5:527-265
  11. Rosenfeld JV, Harvey AS, Wrennall J, et al. Transcallosal resection of intrahypothalamic hamartomas with subsequent remission of seizures in children with gelastic epilepsy. Neurosurgery. 2001;48:108–118
  12. Mullatti N. Hypothalamic hamartoma in adults. Epileptic Disord. 2003;5:201–204
  13. Mullatti N, Selway R, Nashef L, et al. The clinical spectrum of epilepsy in children and adults with hypothalamic hamartoma. Epilepsia. 2003;44:1310–1319
  14. Northfield DW, Russell DS. Pubertas praecox due to a hypothalamic hamartoma: Report of two cases surviving surgical removal of the tumour. J Neurol Neurosurg Psychiatry. 1967;30:166–173
  15. Paillas JE, Roger G, Toga M, et al. Hamarthome de l’hypothalamus. Rev Neurol. 1969;120:177–194
  16. Palmini A, Chandler C, Andermann F, et al. Resection of the lesion in patients with hypothalamic hamartimas and catastrophic epilepsy. Neurology. 2002;58:1338–1347
  17. Regis J, Scavarda D, Tamura M, et al. Epilepsy related to hypothalamic hamartomas: Surgical management with special reference to gamma knife surgery. Childs Nerv Syst. 2006;22:881–895
  18. Delalande O, Fohlen M. Disconnecting surgical treatment of hypothalamic hamartoma in children and adults with refractory epilepsy and proposal of a new classification. Neurol Med Chir (Tokyo). 2003;43:61–68
  19. Nguyen D, Singh S, Zaatreh M, et al. Hypothalamic hamartomas: Seven cases and review of the literature. Epilepsy Behav. 2003;4:246–258
  20. Apuzzo ML, Chikovani OK, Gott PS, et al. Transcallosal, interfornicial approaches for lesions affecting the third ventricle: Surgical considerations and consequences. Neurosurgery. 1982;10:547–554
  21. Apuzzo MLJ, Amar AP. Transcallosal interforniceal approach. In:  Apuzzo MLJ editors. Surgery of the Third Ventricle. (ed 2).. Baltimore, MD: Williams and Wilkins; 1998;p. 421–452
  22. Winkler PA, Weis S, Büttner A, et al. The transcallosal interforniceal approach to the third ventricle: Anatomic and microsurgical aspects. Neurosurgery. 1997;40:973–982
  23. Winkler PA, Weis S, Wenger E, et al. Transcallosal approach to the third ventricle: Normative morphometric data on magnetic resonance imaging scans, with special reference to the fornix and forniceal insertion. Neurosurgery. 1999;45:309–319
  24. Winkler PA, Ilmberger J, Krishnan KG, et al. Transcallosal interforniceal-transforaminal approach for removing lesions occupying the third ventricular space: Clinical and neuropsychological results. Neurosurgery. 2000;46:879–890
  25. Surgery of the Third Ventricle. (ed 2).. Baltimore, MD: Williams and Wilkins; 1998;
  26. Siwanuwatn R, Deshmukh P, Feiz-Erfan I, et al. Microsurgical anatomy of the transcallosal anterior interforniceal approach to the third ventricle. Neurosurgery. 2005;56(suppl 2):390–396
  27. Rosenfeld JV, Freeman JL, Harvey AS. Operative technique: The anterior transcallosal transeptal interforniceal approach to the third ventricle and resection of hypothalamic hamartomas. J Clin Neurosci. 2004;11:738-734
  28. Lawton MT, Golfinos JG, Spetzler RF. The contralateral transcallosal approach: Experience with 32 patients. Neurosurgery. 1996;39:729–734
  29. Freeman JL, Harvey AS, Rosenfeld JV, et al. The evolution and postoperative resolution of symptomatic generalised epilepsy in hypothalamic hamartomas. Neurology. 2003;60:762–767
  30. Feiz-Erfan I, Horn EM, Rekate HL, et al. Surgical strategies for approaching hypothalamic hamartomas causing gelastic seizures in the pediatric population: Transventricular compared with skull base approaches. J Neurosurg (Pediatrics 4). 2005;103:325–332
  31. Rekate HL, Feiz-Erfan I, Ng Y-T, et al. Endoscopic surgery for hypothalamic hamartomas causing medically refractory gelastic epilepsy. Childs Nerv System. 2006;22:847–880
  32. Ng Y-T, Rekate HL, Prenger EC, et al. Transcallosal resection of hypothalamic hamartoma for intractable epilepsy. Epilepsia. 2006;47:1192–1202
  33. Freeman JL, Zacharin M, Rosenfeld JV, et al. The endocrinology of transcallosal hypothalamic hamartoma resection for intractable epilepsy. Epileptic Disord. 2003;5:239–247
  34. Miranda P, Esparza J, Cabrera A, et al. Giant hypothalamic hamartoma operated through subfrontal approach with orbital rim osteotomy. Pediatr Neurosurg. 2006;42:254–257
  35. Ng YT, Rekate HL. Endoscopic resection of hypothalamic hamartoma for refractory epilepsy: Preliminary report. Semin Pediatr Neurol. 2007;14:49–106
  36. Procaccini E, Dorfmüller G, Fohlen M, et al. Surgical management of hypothalamic hamartomas with epilepsy: The stereoendoscopic approach. Neurosurgery (operative). 2005;59:336–346
  37. Choi J-U, Yang K-H, Kim T-G, et al. Endoscopic disconnection for hypothalamic hamartoma with intractable seizure (Report of four cases). J Neurosurg (Pediatrics). 2004;100:506–511
  38. Akai T, Okamoto K, Iizuka H, et al. Treatments of hamartoma with neuroendoscopic surgery and stereotactic radiosurgery: A case report. Minim Invasive Neurosurg. 2002;45:235–239
  39. Lekovic GP, Gonzales LF, Feiz-Erfan I, et al. Endoscopic resection of hypothalamic hamartoma using a novel variable aspiration tissue resector. Operative Neurosurg. 2006;58(suppl 1):166–169
  40. Gore PA, Nakaji P, Deshmukh V, et al. Synchronous endoscopy and microsurgery: A novel strategy to approach complex ventricular lesions. J Neurosurg. 2006;105(suppl 6):485–489
  41. Kuzniecky RI, Guthrie BL. Stereotactic surgical approach to hypothalamic hamartomas. Epileptic Disord. 2003;5:275–280
  42. Schulze-Bonhage A, Homberg V, Trippel M, et al. Interstitial radiosurgery in the treatment of gelastic epilepsy due to hypothalamic hamartomas. Neurology. 2004;62:644–647
  43. Schulze-Bonhage A, Ostertag C. Treatment options for gelastic epilepsy due to hypothalamic hamartoma: Interstitial radiosurgery. Semin Pediatr Neurol. 2007;14:80–87
  44. Quiske A, Frings L, Wagner K, et al. Cognitive functions in juvenile and adult patients with gelastic epilepsy due to hypothalamic hamartoma. Epilepsia. 2006;47:153–158
  45. Ali S, Moriarty J, Mullatti N, et al. Psychiatric comorbidity in adult patients with hypothalamic hamartoma. Epilepsy Behav. 2006;9:111–118

PII: S1071-9091(07)00026-5

doi: 10.1016/j.spen.2007.03.007

Seminars in Pediatric Neurology
Volume 14, Issue 2 , Pages 88-98 , June 2007